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Princess Cruises

10-16 Night Panama Canal Cruises Available

Tick Panama off your list in style

Known as the world’s greatest shortcut, Princess Cruises take you on a once-in-a-lifetime journey through the man-made Panama Canal, from the Atlantic to the Pacific.

Panama cruises from Princess are tailor-made for you when you let our expert advisors at Accent on Travel take care of all the details. With ships that are custom-built to sail both the old and new locks, you get the full experience of this feat of human engineering, as well as the sun-drenched beaches and vibrant colonial cities.

Your Princess Cruises Specialists

Don't miss out, speak to one of our experienced advisors today!

Annette Nero Stellhorn
" Our recent cruise was wonderful and the staff at Accent on Travel did an outstanding job of coordinating all aspects of our vacation! "

– John Morrison

Panama Experiences

Since 1967, Princess Cruises have sailed the Panama Canal, bringing immersive and enriching experiences to each and every passenger - it’s why they’ve been voted “Best Cruise Line for Enrichment” by Cruise International. Walk through UNESCO World Heritage sites in Columbia, Panama City, and Antigua. Sample the local, authentic flavors influenced by Spanish, African, and Native American traditions as you cruise up the western coast of Central America. Whether it’s the Carnaval de Panama Festival held onboard your ship or the diverse adventures ashore, Princess will help you fulfill your dream vacation.

Need inspiration? Here is just a sample of the different onboard and shore-based experiences that await you:

  • Live narration from the bridge traveling through the Panama locks
  • Take an exhilarating zipline ride in Costa Rica
  • Visit sleepy sloths in their rainforest sanctuary
  • Take a dugout canoe to Chagres National Park
  • Tour Guatemala’s most renowned coffee farms
  • Ride the Panama Canal Railway in a 1938 deluxe dome car
  • Wonder at ancient Mayan archaeological sites

Get to know this monumentally important region, enjoy sun-kissed Caribbean beaches, wind your way through rainforests, and stroll through colonial towns. Tell our team what makes the perfect Panama cruise for you and we’ll start planning your itinerary today.

Call our expert advisor today on 888-803-4179

Sample Itinerary - 15-Day Panama Canal Ocean to Ocean

Day 1 | Port: Ft. Lauderdale, Florida
Day 2 | At Sea
Day 3 | At Sea
Day 4 | Port: Cartagena, Colombia
Day 5 | Port: Panama Canal Full Transit New Locks
Day 6 | Port: Fuerte Amador, Panama (for Panama City)
Day 7 | At Sea
Day 8 | Port: Puntarenas, Costa Rica
Day 9 | Port: San Juan del Sur, Nicaragua
Day 10 | At Sea
Day 11 | Port: Huatulco, Mexico
Day 12 | At Sea
Day 13 | Port: Puerto Vallarta, Mexico
Day 14 | At Sea
Day 15 | At Sea

Ends in: Los Angeles, California

Call us about your options!

There’s more to discover from Princess Cruises, including sailings from other US ports like California or Texas, as well as different itineraries to suit everyone.


We can also tailor an excursion package that excites, entertains or gets you closer to authentic Panama.


Call us on 888-803-4179 to discuss the amazing possibilities for your journey!

Princess Cruise Ships in Panama

There’s no one better to guide you with ease and comfort through the Panama Canal than Princess. The Princess fleet offers an onboard experience equally as rich as those you’ll find ashore, with luxury staterooms, freshwater pools and hot tubs, featured guest entertainers, and the adults-only Sanctuary for a tranquil getaway as you sail from ocean to ocean.

We can arrange for you to travel MedallionClass on any of Princess's vessels in Panama, including exclusive perks and benefits that make your journey so much more memorable.

Call our expert advisor today on 888-803-4179

Guides and Articles

Top 5 Reasons to Choose a Princess Cruise

Top 5 Reasons to Choose a Princess Cruise

Read more

Accent on Travel’s Princess Cruises Experts

Want to sail with the cruise line that has more itinerary choices and departures than any other in the region? Our partnership with Princess Cruises means you get more benefits and some unique perks, from complimentary upgrades and shipboard credits to exclusive experience opportunities. That means you’ll be free of worries, giving you more time to make special memories.

Call our expert travel advisors for once-in-a-lifetime Panama cruises with Princess and let us plan your vacation today:

Annette Nero Stellhorn

Bryan Clement

Annette Nero Stellhorn

Reilly Scott

Annette Nero Stellhorn

Kristen Smith

Let's go!

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